FIELD: medicine.
SUBSTANCE: invention concerns medicine, namely to creation of immunogene compositions and vaccines for prevention or treatment of the infections caused by Gram-negative bacteria. The immunogene compositions containing a transferrin-binding fiber and Hsf, and a way of their reception are offered. It is shown, that the combination of these two antigens synergically influences on production of antibodies with high activity in the analysis of bactericidal Serum. The composition can be used in vaccines against Gram-negative bacteria, including Neisseria meningitides, Neisseria gonorrhoeae.
EFFECT: creation of immunogene compositions and vaccines for prevention or treatment of the infections caused by Gram-negative bacteria.
56 cl, 10 ex, 1 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| NEUSSERIAL VACCINE COMPOSITIONS CONTAINING COMBINATION OF ANTIGENS | 2003 |
|
RU2317106C2 |
| IMPROVEMENT OF BACTERIA OUTER MEMBRANE VESICLE | 2003 |
|
RU2325184C2 |
| KIT FOR PREPARING IMMUNOGENIC COMPOSITION FOR SEROGROUP B Neisseria meningitidis | 2008 |
|
RU2498815C2 |
| NMB1125 PROTEIN AND ITS APPLICATION IN PHARMACEUTICAL COMPOSITIONS | 2004 |
|
RU2336900C2 |
| IMPROVEMENTS DEALING WITH MENINGOCOCCUS OUTER MEMBRANE VESICLES | 2005 |
|
RU2420312C2 |
| PROTEIN NMB0928 AND ITS APPLICATION IN PHARMACEUTICAL COMPOSITIONS | 2004 |
|
RU2335505C2 |
| VACCINE COMPOSITIONS CONTAINING L2 AND/OR L3 IMMUNOTYPE LIPOPOLYSACCHARIDES AND ORIGINATED FROM STRAIN NEISSERIA MENINGITIDIS IgtB | 2003 |
|
RU2364418C2 |
| GENES ENCODING MORAXELLA TRANSFERRIN RECEPTOR | 1997 |
|
RU2235128C2 |
| MULTIVALENT VACCINE OF NATIVE VESICLES OF MENINGOCOCCAL OUTER MEMBRANE, METHOD FOR MAKING AND USING IT | 2009 |
|
RU2477145C2 |
| COMPOSITION FOR TREATMENT OR PROPHYLAXIS OF INFECTION CAUSED BY MICROORGANISM NEISSERIA | 2000 |
|
RU2244749C2 |
