FIELD: medicine; pharmacology.
SUBSTANCE: present method of bacteria outer membrane vesicle preparation of Neisseria bacteria implies destruction of bacteria shell and gathering of outer membrane vesicles at deoxycholate solution < 0.05%. Bacteria express surplus NspA. Invention allows to keep significant bacterial immunogenic components, specifically (i) protective surface protein NspA, (ii) protein '287' and (iii) protein '741'.
EFFECT: significant immunogenic components keeping.
17 cl, 2 tbl, 2 dwg
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