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2 359 954

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IPC

C07C49/67(2006-01-01)

C07C59/90(2006-01-01)

C07C69/738(2006-01-01)

C07C69/757(2006-01-01)

C07D307/93(2006-01-01)

A61K31/122(2006-01-01)

A61K31/192(2006-01-01)

A61K31/216(2006-01-01)

A61K31/343(2006-01-01)

A61P31/18(2006-01-01)

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Application

2007111653/04, 2007-03-30

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Start date

2007-03-30

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Actual filing date

2007-03-30

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Published

2009-06-27

(72)

Inventor

Romanov Aleksej NikolaevichSulimov Vladimir BorisovichGottikh Marina BorisovnaBogoljubov Aleksej AlekseevichKondakova Ol'Ga Anatol'EvnaSmolov Maksim AleksandrovichNosik Dmitrij NikolaevichNosik Nikolaj Nikolaevich

(73)

Holder

Obshchestvo S Ogranichennoj Otvetstvennost'Ju Farmasetikl"

BENZOTROPOLONE DERIVATIVES POSSESSING ANTI HIV-ACTIVITY, PHARMACEUTICAL COMPOSITION; METHOD OF HIV-INTEGRASE INHIBITION Russian patent published in 2009 - IPC C07C49/67 C07C59/90 C07C69/738 C07C69/757 C07D307/93 A61K31/122 A61K31/192 A61K31/216 A61K31/343 A61P31/18

Abstract RU 2359954 C2

FIELD: chemistry.

SUBSTANCE: present invention refers to the new benzotropolone derivatives of general structural formula (A) as well to their pharmaceutically acceptable salts possessing anti hiv-activity, to the pharmaceutical composition thereof and to the method of HIV-integrase inhibition. formula (A) where R₁ is selected from the group consisting of the hydrogen and halogen; R₂is selected from the group consisting of the hydrogen and OC_1-6alkyl; each of R₃, R₄, R₅ independently is hydrogen; G is selected from the group consisting of the structures I, II; R₆ is hydrogen; R₇ is COOR₉; R₈ is selected from C_1-6alkyls substituted with one or more halogen atoms; W is O; R₉ is selected from hydrogen or C_1-6alkyl. The structures I, II are represented in the formula of invention.

EFFECT: claimed compounds possess anti HIV-activity.

5 cl, 6 dwg, 13 ex

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RU 2 359 954 C2

Authors

Romanov Aleksej Nikolaevich

Sulimov Vladimir Borisovich

Gottikh Marina Borisovna

Bogoljubov Aleksej Alekseevich

Kondakova Ol'Ga Anatol'Evna

Smolov Maksim Aleksandrovich

Nosik Dmitrij Nikolaevich

Nosik Nikolaj Nikolaevich

Dates

2009-06-27—Published

2007-03-30—Filed