LYSINE-RELATED DERIVATIVES AS HIV ASPARTYL PROTEASE INHIBITORS Russian patent published in 2012 - IPC C07C311/37 C07C311/40 A61K31/18 A61K31/197 A61P31/12

Abstract RU 2458916 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to new lysine-related derivatives of formula (II) and provided a compound of formula (II) contains an amino group, to its pharmaceutically acceptable ammonium salts showing an ability to inhibit HIV protease, to a based pharmaceutical composition and applying them for preparing a drug. , wherein n assumes a value of 3 or 4, X represents H, Y represents a direct or branched alkyl group of 1-6 carbon atoms substituted by -NH₂, R¹ is specified in a group consisting of a branched alkyl group of 3-6 carbon atoms, R² is specified in a group of formula R_2A-CO-, with R_2A specified in an alkoxy group of 1-6 carbon atoms, R³ is specified in a group consisting of a group consisting of a diphenylmethyl group of formula IV wherein X' and Y' are specified in H.

EFFECT: preparing the new lysine-related derivatives.

8 cl, 2 ex

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RU 2 458 916 C2

Authors

Jonkers Tim Kh'Jugo Marija

Dirink Inge

Last Stefan Zhjul'En

De Kok Kherman

Dates

2012-08-20—Published

2007-05-30—Filed