LYSINE COMPOUNDS, PHARMACEUTICAL COMPOSITION CONTAINING THESE COMPOUNDS, APPLICATION OF SAID COMPOUNDS FOR TREATMENT OR PREVENTION OF HIV-INFECTION Russian patent published in 2010 - IPC C07F9/09 C07C311/37 C07D265/30 A61K31/18 A61K31/5375 A61K31/661 A61P31/18 

FIELD: medicine.

SUBSTANCE: present invention concerns lysine compounds of formula (I) or its pharmaceutically acceptable salts, a based pharmaceutical compositions and application for treatment or prevention of HIV-infection. The compounds of formula (I) where n is equal to 3 or 4, where X and Y identical or different are chosen from the group consisting of H, F, Cl, Br, I and -NR₄R₅, where R₆ is chosen from the group consisting of unbranched alkyl group, containing 1 to 6 carbon atoms, and branched alkyl group containing 3 to 6 carbon atoms, where R₃ is chosen from the group consisting of the group of formula R_3A-CO-, and R_3a is chosen from the group consisting of unbranched or branched alkyl group containing 1 to 6 carbon atoms, alkyloxygroup containing 1 to 6 carbon atoms, and 4-morpholinyl, where R₄ and R₅ are identical and represent H, where R₂ is chosen from the group consisting of diphenylmethyl group, naphthyl-1-CH₂-group, and naphthyl-2-CH₂-group, where X' and Y' are identical and represent H, and where R₁ is chosen from the group consisting of from (HO)₂P(O) and (MO)₂P(O), where M represents alkaline metal.

EFFECT: lysine compounds representing effective inhibitors of aspartyl-protease.

15 cl, 3 tbl, 1 ex