FIELD: biotechnology and medicine.
SUBSTANCE: recombinant adenoviral vector Ad6/3-hTERT-GMCSF with antitumor specificity has been described. The vector contains nucleotide sequences expressing a modified fibre protein of adenovirus serotype 6, in which the knob domain is replaced by a similar domain of adenovirus serotype 3.
EFFECT: invention expands the range of medicinal products for the treatment of cancer, both in monotherapy and in combination with other therapeutic approaches, such as immunotherapy, chemotherapy, and radiotherapy.
1 cl, 6 dwg, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ONCOLYTIC ADENOVIRUS FOR TREATING CANCER, USING IT, AND PHARMACEUTICAL COMPOSITION CONTAINING IT | 2010 |
|
RU2536931C2 |
| COATED ONCOLYTIC ADENOVIRUS FOR ANTICANCER VACCINES | 2015 |
|
RU2695375C2 |
| DESIGNING OF CARCINOLYTIC ADENOVIRUS RECOMBINANT, SPECIFICALLY EXPRESSING IMMUNOMODULATORY FACTOR GM-CSF IN TUMORAL CELLS AND ITS APPLICATION | 2004 |
|
RU2361611C2 |
| ADENOVIRUS CONTAINING ALBUMIN-BINDING SITE | 2015 |
|
RU2711371C2 |
| EXTENDED ADOPTIVE CELL THERAPY | 2014 |
|
RU2703438C2 |
| RECOMBINANT ONCOLYTIC STRAIN OF THE VACCINIA VIRUS L-IVP_ONCOB, CONTAINING GENES, ENCODING GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR AND POLYEPITOPE IMMUNOGEN, CONSISTING OF EPITOPES OF ANTIGENS, HYPER EXPRESSING BY TUMOR CELLS IN BREAST CANCER | 2017 |
|
RU2678056C1 |
| RECOMBINANT STRAIN VV-GMCSF-S1/3 OF VACCINIA VIRUS, PRODUCING SECRETED GRANULOCYTE-MACROPHAGE COLONY-STIMULATING HUMAN FACTOR | 2013 |
|
RU2565544C2 |
| RECOMBINANT ONCOLYTIC STRAIN OF L-IVP_ONCOQ VACCINIA VIRUS, CONTAINING GENES ENCODING GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR AND POLYEPITOPE IMMUNOGEN CONSISTING OF ANTIGEN EPITOPES, OVEREXPRESSING TUMOR CELLS IN OVARIAN CANCER | 2017 |
|
RU2678003C1 |
| RECOMBINANT VARIOLOVACCINE VIRUS STRAIN VV-NS1-dGF PRODUCING NS1 PARVOVIRUS H-1 PROTEIN AND HAVING ONCOLYTIC ACTIVITY ON HUMAN GLIOBLASTOMA | 2018 |
|
RU2692628C1 |
| RECOMBINANT STRAIN VV-GMCSF-Lact OF VACCINIA VIRUS, HAVING ONCOLYTIC ACTIVITY AND PRODUCING GRANULOCYTIC-MACROPHAGAL COLONY-STIMULATING FACTOR AND ONCOTOXIC LACTAPTIN PROTEIN | 2015 |
|
RU2604187C1 |
