FIELD: biotechnology.
SUBSTANCE: described is an anticancer composition containing a tumor-specific oncolytic adenovirus and an immune response control point inhibitor. A recombinant adenovirus with inserted IL-12 and shVEGF or IL-12 and GM-CSF-RLX genes.
EFFECT: invention exhibits an excellent anti-cancer effect by enhancing immune functions, and has been confirmed, that such anticancer effect is markedly enhanced by simultaneous introduction of an immune response with an inhibitor of the control point, and thus the present invention can be used as a key technique in treating cancer.
10 cl, 1 ex, 23 dwg
| Title |
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