AGENT STRENGTHENING EFFECT OF PROCESSING BY FOCUSED ULTRASOUND OF HIGH INTENSITY, AND WAY OF SCREENING OF GIVEN AGENT Russian patent published in 2009 - IPC A61K49/00 A61P35/00 

FIELD: medicine.

SUBSTANCE: group of inventions concerns medicine, namely to the agents strengthening effect of processing by focused ultrasound of high intensity (HIFU). The agent, strengthening effect of HIFU processing, intended for HIFU-therapy, represents a substance which can reduce level of HIFU energy in a target site (EEF), containing the discrete phase consisting of a kernel, concluded in a capsule from a membrane-forming substance; and the continuous phase consisting of water medium, thus the discrete phase is homogeneously distributed in the continuous phase. The way of processing of a target site using the HIFU method consists in intravenous introduction of an effective dose of the specified strengthening agent by means of continuous and fast intravenous installation or bolus injection to the patient 0-168 hours prior to HIFU-therapy application. The way of an agent screening strengthening effect of HIFU processing, consists in HIFU-therapy application - to a concrete tissue, calculation of EEF_(initial) energy, introduction of a strengthening agent-candidate in a biological tissue, measurement of EEF_(experim.) energy, comparison of EEF_(initial) and EEF_(experim.), and in a choice of the strengthening agent-candidate concerning EEF_(initial) to EEF_(initial) it is more than 1. The given group of inventions allows reducing quantity of the acoustic energy necessary for damage of a target tissue, in unit of volume of a tissue in the course of HIFU processing, to reduce time of processing of target area and to improve therapeutic effects.

EFFECT: reduction of quantity of the acoustic energy necessary for damage of a target tissue, in unit of volume of a tissue in the course of HIFU processing, reduction of time of processing of target area and improvement of therapeutic effects.

19 cl, 24 ex, 10 tbl