FIELD: medicine.
SUBSTANCE: invention concerns medicine, in particular to immunology, and concerns the way of estimation of joint action of glucocorticoids and intrleukin-7 on functional maturing of T-lymphocytes of newborns. The way consists in stimulation of T-lymphocytes maturing process in a cell culture with glucocorticoids and interleukin-7 with the subsequent calculation of the synergistic action index of glucocorticoids and interleukin-7 as relation of T-cells quantity producing interferon in cell cultures with antibodies, interleukin-7 and glucocorticoids added to quantity of interferon producers in cell cultures where only antibodies and interleukin-7 are added; and at value of the index more than 1.0, - conclusion about stimulation of functional maturing of T-lymphocytes under the influence of glucocorticoids and interleukin-7 is made.
EFFECT: possibility to carry out fundamental and clinical researches of specific mechanisms regulating aging of T-lymphocytes of newborns.
2 dwg, 2 ex
Title | Year | Author | Number |
---|---|---|---|
METHOD FOR DETECTING FUNCTIONAL ACTIVITY OF CYTOKINS THAT SUPPRESS T-LYMPHOCYTES IN NEONATALS | 2003 |
|
RU2246732C2 |
METHOD FOR INTERFERON-GAMMA PRODUCING T-LYMPHOCYTE TEST IN CHRONIC LYMPHATIC LEUKAEMIA | 2012 |
|
RU2526797C2 |
MEDICINAL PREPARATION TO PREVENT TRANSPLANT DETACHMENT, MONOCLONAL ANTIBODY TO CD3 ANTIGEN OF HUMAN T-LYMPHOCYTES, HYBRIDOME AND METHOD TO TREAT PATIENTS SUFFERING ACUTE TRANSPLANT DETACHMENT REACTION FOLLOWING KIDNEY TRANSPLANTATION | 2000 |
|
RU2179862C1 |
MODULATION OF EXPRESSION OF CYTOKINES TH1/TH2 BY RIBAVIRIN AND RIBAVIRIN ANALOGS IN ACTIVATED T-LYMPHOCYTES | 1997 |
|
RU2186569C2 |
MUS MUSCULUS'S HYBRID CULTURE CELL STRAIN α PRODUCING MONOCLONAL ANTIBODIES SPECIFIC TO HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR (GCSF) | 2013 |
|
RU2542381C2 |
GAMMA-INTERFERON INDUCTOR | 2003 |
|
RU2254861C1 |
COMPOSITIONS AND METHODS FOR INHIBITION OF STEM CELLS AND PRECURSOR CELLS BINDING WITH LYMPHOID TISSUE AND FOR REGENERATION OF GERMINAL CENTERS IN LYMPH TISSUES | 2011 |
|
RU2645069C2 |
DIAGNOSTIC TECHNIQUE FOR DISPOSITION TO ATHEROSCLEROSIS PROGRESSION IN PATIENTS WITH CHRONIC ISCHEMIC HEART DISEASES BY PERIPHERAL BLOOD INTERLEUKIN-10-PRODUCING LYMPHOCYTE COUNT | 2014 |
|
RU2575791C1 |
METHOD FOR PREVENTING INFLUENZA BY COMBINED APPLICATION OF INTERFERON GAMMA AND INACTIVATED ANTI-INFLUENZA VACCINE | 2011 |
|
RU2546540C2 |
STRAIN CULTIVATED PAPIO HAMADRYLAS CELLS USED FOR OBTAINING LYMPHOTROPHIC PAPIO RETROVIRUS, TYPE C AND A, AS TEST OBJECT FOR CHARACTERIZING MONOCLONAL ANTIBODIES WITH T-CELL SPECIFICITY | 0 |
|
SU1774949A3 |
Authors
Dates
2009-08-10—Published
2007-05-30—Filed