ROENTGEN-AMORPHOUS WATER-FREE MODIFICATION OF 4-[(4-METHYL-1-PIPERAZINYL)METHYL]-N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]-AMINO]-PHENYL]BENZAMIDE OF METHANE SULFONATE AND METHOD OF OBTAINING IT Russian patent published in 2009 - IPC C07D403/04 A61K31/506 A61P35/00

Abstract RU 2365587 C1

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and describes novel roentgen-amorphous modification of 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]-amino]-phenyl]benzamide of methane sulfonate (imatinib mesilate - international non-patented name) and method of obtaining it, consisting in evaporating initial substance of imatinib mesilate at temperature 170-215°C in vacuum 5×10^-3 - 3×10^-5 torr and condensing on cooled to (-)100 - (-)196°C surface.

EFFECT: obtaining of novel imatinib mesilate modification which can be used in pharmaceutical industry and medicine as anti-leucosis cytostatic medication for therapy of oncological diseases.

2 cl, 6 ex, 7 dwg

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RU 2 365 587 C1

Authors

Shabatin Vladimir Petrovich

Morozov Jurij Nikolaevich

Sergeev Gleb Borisovich

Dates

2009-08-27—Published

2008-02-22—Filed