Show metadata Hide metadata

(19)

(11)

2 430 094

(13)

(51)

IPC

C07D243/24(2006-01-01)

C07D243/26(2006-01-01)

A61K31/5513(2006-01-01)

A61P25/22(2006-01-01)

(21) (22)

Application

2010109873/04, 2010-03-17

(24)

Start date

2010-03-17

(22)

Actual filing date

2010-03-17

(45)

Published

2011-09-27

(72)

Inventor

Morozov Jurij NikolaevichSergeev Boris MikhajlovichKolotilov Pavel NikolaevichShabatin Vladimir PetrovichSergeev Gleb BorisovichChernyshev Vladimir Vasil'EvichVoronina Tat'Jana AleksandrovnaMolodavkin Gennadij Matveevich

(73)

Holder

Gosudarstvennoe Uchebno-Nauchnoe Uchrezhdenie Khimicheskij Fakul'Tet Moskovskogo Gosudarstvennogo Universiteta Imeni M.V. LomonosovaSergeev Gleb Borisovich

CRYSTALLINE BETA-MODIFICATION OF 7-BROMO-1,3-DIHYDRO-5-(2-CHLOROPHENYL)-2H-1,4-BENZODIAZEPIN-2-ONE AND SYNTHESIS METHOD THEREOF Russian patent published in 2011 - IPC C07D243/24 C07D243/26 A61K31/5513 A61P25/22

Abstract RU 2430094 C1

FIELD: chemistry.

SUBSTANCE: described is a novel crystalline β-modification of 7-bromo-1,3-dihydro-5-(2-chlorophenyl)-2H-1,4-benzodiazepin-2-one (phenazepam) and synthesis method thereof, which can be used in pharmaceutical industry and medicine as a tranquilliser. Said novel crystalline β-modification of 7-bromo-1,3-dihydro-5-(2-chlorophenyl)-2H-1,4-benzodiazepin-2-one is characterised by certain interplanar spacing (A⁰) and corresponding intensity and parameters of the crystal lattice, given in the claims.

EFFECT: marked muscle relaxant, soporific, anticonvulsant and anxiolytic action.

2 cl, 7 ex, 2 tbl, 9 dwg

Similar patents RU2430094C1

Title	Year	Author	Number
COMPOSITION FOR INJECTIONS BASED ON CRYSTALLINE β-MODIFICATION OF 7-BROM-1,3-DIHYDRO-5-(2-CHLORPHENYL)-2H-1,4-BENZODIAZEPIN-2-ONE EXHIBITING TRANQUILISING ACTION AND METHOD FOR PREPARING IT	2010	Morozov Jurij Nikolaevich Kolotilov Pavel Nikolaevich Shabatin Vladimir Petrovich Sergeev Gleb Borisovich Chernyshev Vladimir Vasil'Evich Voronina Tat'Jana Aleksandrovna Molodavkin Gennadij Matveevich	RU2440120C1
CRYSTALLINE MODIFICATION OF 3β-HYDROXY-5-ANDROSTEN-17-ONE FVII AND METHOD FOR PRODUCTION THEREOF	2013	Morozov Jurij Nikolaevich Utekhina Anastasija Jur'Evna Sergeev Gleb Borisovich Chernyshev Vladimir Vasil'Evich Chistjakov Viktor Vladimirovich Goncharov Nikolaj Petrovich Rzheznikov Vladimir Markovich	RU2528990C1
CRYSTALLINE β-MODIFICATION OF 2,3-BIS-(HYDROXYMETHYL)QUINOXALINE-N,N'-DIOXIDE, METHOD OF THEREOF OBTAINING AND THEREOF-BASED PHARMACEUTICAL COMPOSITION	2014	Shabatin Vladimir Petrovich Vernaja Ol'Ga Ivanovna Semenov Aleksandr Mikhajlovich Shabatina Tat'Jana Igorevna	RU2563256C1
ROENTGEN-AMORPHOUS WATER-FREE MODIFICATION OF 4-[(4-METHYL-1-PIPERAZINYL)METHYL]-N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]-AMINO]-PHENYL]BENZAMIDE OF METHANE SULFONATE AND METHOD OF OBTAINING IT	2008	Shabatin Vladimir Petrovich Morozov Jurij Nikolaevich Sergeev Gleb Borisovich	RU2365587C1
CRYSTALLINE β-MODIFICATION OF 3-(4-AMINO-1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)-PIPERIDINE-2,6-DIONE, METHOD OF ITS PRODUCTION AND PHARMACEUTICAL COMPOSITION BASED THEREON	2016	Mikhajlov Oleg Rostislavovich Uvarov Nikolaj Aleksandrovich Malin Aleksandr Aleksandrovich	RU2616976C1
PHARMACEUTICAL COMPOSITION AND MEDICINAL AGENT BASED ON CLATHRATE COMPLEX OF 7-BROM-5-(ORTHO-CHLOROPHENYL)-2,3-DIHYDRO-1H-1,4-BENZODIAZEPIN-2-ONE AND CYCLODEXTRIN, METHODS FOR PRODUCING IT (VERSIONS)	2014	Ismagilov Iskandar Khaliullovich	RU2570382C1
CRYSTAL BETA-MODIFICATION OF (E)-DIMETHYL BUTENEDIOATE, METHOD FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION ON ITS BASIS	2016	Mikhajlov Oleg Rostislavovich Uvarov Nikolaj Aleksandrovich Malin Aleksandr Aleksandrovich	RU2616605C1
WEAKLY CRYSTALLISED β-MODIFICATION OF (S)-ISOPROPYL 2-((S)-(((2R,3R,4R,5R)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-(2H)-YL)-4-FLUORO-3-HYDROXY-4-METHYLTETRAHYDROFURAN-2-YL)METHOXY)-(PHENOXY)PHOSPHORYLAMINO)PROPANOATE, METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITION BASED THEREON	2017	Mikhajlov Oleg Rostislavovich Uvarov Nikolaj Aleksandrovich Malin Aleksandr Aleksandrovich	RU2656228C9
CRYSTALLINE ε-MODIFICATION OF N-[2-(DIETHYLAMINO)ETHYL]-5-[(Z)-(5-FLUOR-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE)METHYL]-2,4-DIMETHYL-1H-PYRROL-3-CARBOXAMIDE MALATE, METHOD FOR PRODUCING SAME AND BASED PHARMACEUTICAL COMPOSITION	2014	Malin Aleksandr Aleksandrovich Mikhajlov Oleg Rostislavovich Uvarov Nikolaj Aleksandrovich	RU2567535C1
METHOD OF PRODUCING 7-BROMO-5-(2-CHLOROPHENYL)-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE	2015	Novakov Ivan Aleksandrovich Pletneva Mariya Yurevna Navrotskij Maksim Borisovich Kameneva Irina Yurevna Brunilina Lejla Lipparitovna Babushkin Aleksandr Sergeevich	RU2599988C1

RU 2 430 094 C1

Authors

Morozov Jurij Nikolaevich

Sergeev Boris Mikhajlovich

Kolotilov Pavel Nikolaevich

Shabatin Vladimir Petrovich

Sergeev Gleb Borisovich

Chernyshev Vladimir Vasil'Evich

Voronina Tat'Jana Aleksandrovna

Molodavkin Gennadij Matveevich

Dates

2011-09-27—Published

2010-03-17—Filed