FIELD: medicine.
SUBSTANCE: invention relates to pharmacy. The method for making storage-stable multicomponent water/oil/water emulsions which contain one or more biologically active substances includes the stage a) that involves a biologically active substance added in an aqueous phase, the stage b) that involves the aqueous phase emulsified by addition to an oil phase through a loose membrane, and the stage c) that involves phase inversion in the emulsion from the stage b) by cooling the mixture at low rate 0.3 K/min. An emulsifier is added to the aqueous phase at the stage a) and/or to the oil phase at a stage b).
EFFECT: invention provides the identical external and internal aqueous phases containing the same amount of the active substance, with immediate release of the active substance from the external phase and slow release thereof from the internal phase.
12 cl, 1 tbl, 4 ex, 2 dwg
Title | Year | Author | Number |
---|---|---|---|
COMPOSITION OF VACCINES WITH DOUBLE ADJUVANT, PREPARATION AND USE | 2015 |
|
RU2729646C2 |
MUCROFLUIDIC OIL-IN-WATER EMULSION AND VACCINE COMPOSITIONS | 2004 |
|
RU2541809C2 |
MICROFLUIDISED OIL-IN-WATER EMULSIONS AND VACCINE COMPOSITIONS | 2005 |
|
RU2347586C2 |
MICRON AND SUBMICRON-SIZE MICROBEADS WITH POLYMER WRAP AND METHOD OF MANUFACTURING THEREOF | 1991 |
|
RU2110991C1 |
STABLE EMULSIONS OF BACTERIAL ANTIGENS | 2019 |
|
RU2805210C2 |
METHOD FOR PRODUCTION OF MICROPARTICLES BY DOUBLE EMULSION METHOD | 2018 |
|
RU2776379C2 |
METHOD FOR PREPARING VACCINE COMPOSITION CONTAINING AT LEAST ONE ANTIGEN AND AT LEAST ONE ADJUVANT | 2008 |
|
RU2500421C2 |
EMULSIONS STABILISED BY PARTICLES OF EDIBLE INORGANIC SALT | 2014 |
|
RU2667744C1 |
NEW VACCINE FORMULATIONS CONTAINING SAPONIN-CONTAINING ADJUVANTS | 2010 |
|
RU2555342C2 |
EMULSIONS OF “OIL-IN-WATER” TYPE, WHICH CONTAIN NUCLEIC ACIDS | 2012 |
|
RU2606846C2 |
Authors
Dates
2009-09-20—Published
2004-10-29—Filed