METHOD FOR MAKING STORAGE-STABLE MULTICOMPONENT EMULSIONS Russian patent published in 2009 - IPC A61K9/113 A61P43/00 

Abstract RU 2367411 C2

FIELD: medicine.

SUBSTANCE: invention relates to pharmacy. The method for making storage-stable multicomponent water/oil/water emulsions which contain one or more biologically active substances includes the stage a) that involves a biologically active substance added in an aqueous phase, the stage b) that involves the aqueous phase emulsified by addition to an oil phase through a loose membrane, and the stage c) that involves phase inversion in the emulsion from the stage b) by cooling the mixture at low rate 0.3 K/min. An emulsifier is added to the aqueous phase at the stage a) and/or to the oil phase at a stage b).

EFFECT: invention provides the identical external and internal aqueous phases containing the same amount of the active substance, with immediate release of the active substance from the external phase and slow release thereof from the internal phase.

12 cl, 1 tbl, 4 ex, 2 dwg

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RU 2 367 411 C2

Authors

Shtange Olaf

Mutter Martina

Osval'D Tanja

Shmitts Mark

Dates

2009-09-20Published

2004-10-29Filed