COMPOSITION OF VACCINES WITH DOUBLE ADJUVANT, PREPARATION AND USE Russian patent published in 2020 - IPC A61K39/12 A61K39/112 A61P31/00 

FIELD: medicine; veterinary.

SUBSTANCE: group of inventions can be used to produce a vaccine for inducing an immune response against chicken salmonella. Vaccine comprises an effective amount of at least one antigen and an adjuvant compound in an emulsion of water-oil-water (WOW) type, wherein at least one antigen is a combination of bacteria Salmonella Enteritidis, Salmonella Kentucky and Salmonella Typhimurium. Adjuvant compound is aluminum hydroxide, WOW emulsion contains aqueous vesicles enclosed in oil particles, wherein said oil particles have size smaller than 20 mcm and are dispersed in external aqueous phase, and at least 60 % (w/w) of the total amount of said at least one antigen in the vaccine is contained in the oil particles. Group of inventions also relates to a method for preparing said vaccine and to a method for chicken vaccination.

EFFECT: use of this group of inventions enables to obtain a chicken salmonella vaccine, in particular, containing a combination of antigens Salmonella Enteritidis, Salmonella Kentucky and Salmonella Typhimurium and a double adjuvant providing enhanced immune response.

15 cl, 4 ex, 8 tbl, 6 dwg