METHOD OF ACUTE PYELONEPHRITIS SIMULATION WITH UNDERLYING COLD STRESS Russian patent published in 2009 - IPC G09B23/28 

FIELD: medicine.

SUBSTANCE: invention refers to experimental medicine, namely to experimental nephrology and can be used for acute pyelonephritis simulation with underlying cold stress. It is ensured by single rectal introduction to a laboratory animal through enema after bowel voiding of daily broth culture of uropathogenic strain of clinical isolate of lactose-negative Escherichia coli concentrated 10⁵-10⁷ CFU/ml, recovered from urine of the patient with acute pyelonephritis and possessing uropathogenic properties. On day following infection, an animal is exposed to acute cold stress at t°=0+2°C within 2 hours.

EFFECT: reproducibility of renal infectious-inflammatory process similarly to that observed in clinic, without doing an animal a surgical trauma.

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