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(19)

(11)

2 368 604

(13)

(51)

IPC

C07D333/20(2006-01-01)

C07D405/12(2006-01-01)

C07D405/14(2006-01-01)

C07D401/12(2006-01-01)

A61K31/44(2006-01-01)

A61P25/28(2006-01-01)

(21) (22)

Application

2005104819/04, 2003-07-21

(24)

Start date

2003-07-21

(22)

Actual filing date

2003-07-21

(45)

Published

2009-09-27

(72)

Inventor

Shumakher Richard A.Khopper Allen T.Tekhim AshokKhess Khans-Jurgen EhrnstUnterbekk AkselKjuster EhrikBrubejker Dzhr. Uill'Jam FrederikDann Robert F.

(73)

Holder

Memori Farmas'Jutiklz Korporejshn

PHOSPHODIESTARASE 4 INHIBITORS, CONTAINING N-SUBSTITUTED ANILINE AND DIPHENYLAMINE ANALOGUES Russian patent published in 2009 - IPC C07D333/20 C07D405/12 C07D405/14 C07D401/12 A61K31/44 A61P25/28

Abstract RU 2368604 C2

FIELD: chemistry.

SUBSTANCE: invention relates to N-substituted aniline and diphenylamine analogues, chosen from 3,4-bisdifluoromethoxy-(3-carboxyphenyl)-N-(5-(2-chloropyridinylmethyl))-aniline, 3,4-bisdifluoromethoxy - N-(3-carboxyphenyl) - N-(3-(2-chloropyridylmethyl))-aniline, 3,4 - bisdifluoromethoxy - N-(3-carboxyphenyl) - N-(4-(3,5-dimethylisoxazolylmethyl)) aniline, 3 - cyclopentyloxy - 4-methoxy - N-(3-aminocarbonylphenyl) - N-(3-pyridylmethyl) aniline and other compounds given in paragraph 1 of the formula of invention and to their pharmaceutically acceptable salts as inhibitors of PDE4 enzyme.

EFFECT: compounds can be used for treating and preventing diseases caused by activity of the PDE4 enzyme.

15 cl, 8 dwg, 58 ex

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RU 2 368 604 C2

Authors

Shumakher Richard A.

Khopper Allen T.

Tekhim Ashok

Khess Khans-Jurgen Ehrnst

Unterbekk Aksel

Kjuster Ehrik

Brubejker Dzhr. Uill'Jam Frederik

Dann Robert F.

Dates

2009-09-27—Published

2003-07-21—Filed