METHOD OF OBTAINING PHARMACEUTICAL COMPOSITION FOR ORAL INTRODUCTION POSSESSING IMPROVED BIOACCESSIBILITY OF BIOLOGICALLY ACTIVE EFFECTIVE MEDICINAL SUBSTANCE, AND PHARMACEUTICAL COMPOSITION OBTAINED BY SAID METHOD Russian patent published in 2009 - IPC A61K31/5517 A61K31/4196 A61K47/38 A61K47/00 A61K9/20 A61J3/10 A61P25/22 A61P25/24 

FIELD: medicine.

SUBSTANCE: method of obtaining tablets containing crystalline-form-free alprazolam, includes at preliminary stage of granulation operation obtaining alprazolam solution in pharmacologically acceptable solvent together with crystallisation-inhibiting agent, formed by mixture of binding substance and from 20 to 60% wt of total amount of lubricating substance, impregnation with obtained solution of mixture of diluent and 25% reticular carboxymethylcellulose as disintegrating agent until homogeneous granulated mass is obtained and grinding of obtained granulated mass, preliminarily dried, until grinded granulometrically homogeneous mass is obtained. At the second stage of granulation operation, 100% of remaining lubricating agent and remaining reticular carboxymethylcellulose and aromatising additives are added to dried and grinded mass, obtained at preliminary stage of granulation operation; aromatised mass is finally mixed and pressed. Non-crystalline state of alprazolam improves its solvability and bioaccessibility.

EFFECT: alprazolam tablets have smaller size than traditional tablets, and disintegration time less than 1 minute, preferably, less than 30 seconds.

11 cl, 7 dwg, 3 tbl, 3 ex