RECOMBINANT YEAST STRAIN HARSENULA POLYMORPHA - PRODUCER OF THE MAIN CAPCID PROTEIN L1 OF HUMAN PAPILLOMAVIRUS TYPE 11 Russian patent published in 2018 - IPC C12N1/15 C12N15/37 C07K14/25 

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, particularly to genetic engineering. Yeast strain Hansenula polymorpha, a producer of the recombinant L1 protein of human papillomavirus (HPV) type 11, is proposed. Strain was obtained by introducing a single copy of the DNA sequence encoding the HPV type 11 L1 capsid protein into the yeast cell genome, under the control of the promoter DAK, and one copy of the DNA sequence that encodes the capsid protein L1 of HPV type 11, under the control of the MOX promoter. Strain provides a high yield of recombinant HPV L1 protein, which has antigenic and immunogenic properties of the natural antigen.

EFFECT: invention can be used for microbiological production of recombinant L1 protein of HPV type 11.

1 cl, 2 dwg, 1 tbl, 9 ex