METHOD OF INTEGRATED TREATMENT OF LOCALLY ADVANCED MALIGNANT BRONCHIAL AND/OR TRACHEAL TUMOURS Russian patent published in 2009 - IPC A61N5/10 A61K31/409 A61K31/282 A61K31/7068 A61K31/427 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention concerns medicine, oncology, and can be used for integrated treatment of locally advanced malignant bronchial and/or tracheal tumours. It is ensured by argon-plasma recanalisation of bronchial and/or tracheal lumen at power 60-90 W. It is followed with photodynamic therapy with using a preparation Photoditasine 1.5 mg/kg and semiconductor laser light of wavelength 662 nm at power density of 300 mW/cm² of total power dose 400 J/cm². Combined radiation therapy includes brachytherapy and remote radiation therapy. Herewith brachytherapy is performed at source motion path length 5-20 cm of step 5 mm and reference isodose depth 10 mm from the source with an applicator enabled to travel above and below the tumour 1 to 3 cm and ensured dose 14-28 Gy in the mode 7 Gy once a week. Remote radiation therapy is carried out 5 times a week 1-2 Gy up to "СОД" 45-55 Gy. In addition, the radiation is accompanied with 4 courses of chemotherapeutical intravenous infusions of cisplatin in a dose 100 mg/m² in the 1^st day with gemcitabine in a dose 1000 mg/m in the 1^st, 8^th, 15^th days every 4 weeks. Besides, cisplatin is allowed in a dose 80 mg/m² in the 1^st day with etoposide in a dose 120 mg/m² in 1^st, 3^rd, 5^th days every 3 weeks.

EFFECT: invention ensures reduction of tumour burden, recovered patency of airways, managed inflammation, intoxication and pain syndrome, local and system antineoplastic action of chemotherapy, longer and improved life quality of the patients.

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