INTEGRATED TREATMENT OF MALIGNANT TUMOUR PLEURA INVOLVEMENT ACCOMPANIED WITH EXUDATIVE PLEURISY Russian patent published in 2009 - IPC A61N5/67 A61N1/44 A61B18/04 A61K31/282 A61P35/00 

FIELD: medicine.

SUBSTANCE: integrated treatment of malignant tumour pleura involvement accompanied with exudative pleurisy is ensured with argon-plasma electrocoagulation of pleura at power 60-90 Wt and argon consumption 2.0-2.4 l/min followed with intraoperative photodynamic therapy. A photosensitiser is Photoditasine dosed 1.5 mg/kg. The irradiation involves diode laser of wavelength 662 nm and power density 300 mWt/cm², at total energy dose 400 J/cm². In addition, it is combined with hyperthermic intrapleural chemoperfsion of cisplatin 100 mg in 1500-3000 ml of 0.9 % sodium chloride solution at temperature 42°C within 60 minutes at feed rate 1200 ml/min.

EFFECT: reduced tumour weight, terminated exudation and protein loss, reduced inflammation, intoxication and pain syndrome, local and systemic cytostatic action of cisplatin.

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