NEW TRIARYLIMIDAZOLES Russian patent published in 2009 - IPC C07D401/14 A61K31/506 A61P35/00 

Abstract RU 2372346 C2

FIELD: chemistry.

SUBSTANCE: invention relates to new compounds of formula (I) and pharmaceutically acceptable salts of the said compound, which has c-met kinase inhibitory properties. In general formula (I) W is -N=, and X is hydrogen, Y is hydrogen or A2-R group; A2 is C1-C5alkylene; R is hydroxy; n equals 1, and Z is benzyloxy; or alternatively W is -CH=, and X is hydrogen, OR1; R1 is chosen from A1-Q1group; A1 is 1,2-ethylene or 1,3-propylene group; Q1 is hydroxyl; Y is a A2-R group; A2 is C1-C5alkylene; R is hydroxy; n equals 1, and Z is C1-C3alkoxy, substituted with pyridinyl, and pharmaceutically acceptable salts of the said compound.

EFFECT: can be used for treating cancer and cancer-related diseases.

8 cl, 36 ex

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RU 2 372 346 C2

Authors

Fon-Khirshkhejdt Tomas

Foss Ehdgar

Dates

2009-11-10Published

2004-10-15Filed