FIELD: chemistry.
SUBSTANCE: present invention refers to the new naphtylene derivative having general formula (I-A) and to their pharmaceutically acceptable salts having the property of inhibition of the cytochrome ferment P450RAI (Cyp26) activity, to the pharmaceutic composition thereof and to the method of inhibition of cytochrome ferment P450RAI (Cyp26). 
, wherein X is selected from imidasolyl or triasolyl; R2 and R3, independently represent H, C1-10-alkyl; G1 is -NR72R82 or G1 and R3 taken together with attached carbon atom form 3-10-membered saturated ring or heterocyclic saturated ring containing N as heteroatom which is optionally substituted with substituting group R72, Z, R4b, R5b, Q1, R72, n2, n3 and n4 values are indicated in the formula of the invention.
EFFECT: present invention refers to the intermediates for compounds with general formula (I-A) and to their pharmaceutic salts thereof.
37 cl, 30 dwg, 7 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| ISOXAZOLINES AND ISOXAZOLES, METHOD OF INHIBITION OF PLATELET AGGREGATION, PHARMACEUTICAL COMPOSITION INHIBITING PLATELET AGGREGATION | 1994 |
|
RU2149871C1 |
| 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEINKINASE INHIBITORS | 2005 |
|
RU2379308C2 |
| DERIVATIVES OF SPIRO-[ISOQUINOLINE-4-(1H)-3-PYRROLIDINE]-1,2',3,5'-(2H)-TETR- -ONE, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION USED FOR PREVENTION OR TREATMENT OF DIABETES MELLITUS-RELATED COMPLICATIONS | 1991 |
|
RU2110518C1 |
| PROLYL HYDROXYLASE INHIBITORS AND APPLICATION METHODS THEREOF | 2007 |
|
RU2429226C9 |
| NEW COMPOUNDS AND THEIR PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF INFLAMMATORY DISEASES | 2018 |
|
RU2785126C2 |
| CFTR REGULATORS AND METHODS OF USING | 2016 |
|
RU2730855C2 |
| ANDROGEN RECEPTOR MODULATORS AND METHODS FOR THEIR USE | 2019 |
|
RU2797622C2 |
| IMIDAZOPYRAZINES AS TYROSINE KINASE INHIBITORS | 2004 |
|
RU2405784C2 |
| PYRAZOLE DERIVATIVES APPLIED AS PROTEIN KINASE INHIBITORS | 2001 |
|
RU2340611C2 |
| PYRAZOLOTRIAZINE DERIVATIVES AS SELECTIVE INHIBITORS OF CYCLIN-DEPENDENT KINASES | 2013 |
|
RU2645347C2 |
