FIELD: chemistry.
SUBSTANCE: invention relates to a method of making a nanosised system for delivering met-enkephalin on a hydrosol of SiO2 nanoparticles, involving mixing distilled water, hydrochloric acid and tetraethoxysilane, addition of a prepared NaOH solution, evaporation and filtration, obtaining a SiO2 hydrosol, ultrasonic treatment of the obtained SiO2 hydrosol, addition of met-enkephalin and surfactant solution in amount ranging from 0.5 to 2% of total volume of the obtained system.
EFFECT: system of delivering met-enkephalin is capable of penetrating the hematoencephalic barrier and deliver medicinal agents to brain cells.
2 ex, 2 tbl
| Title | Year | Author | Number |
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| METHOD FOR PRODUCING AGENT FOR INTRACELLULAR DELIVERY OF BIOLOGICALLY ACTIVE LOW-MOLECULAR NANOPARTICLE-BASED COMPOUNDS | 2014 |
|
RU2557987C1 |
| AGENT FOR INTRACELLULAR DELIVERY OF BIOLOGICALLY HIGH-MOLECULAR COMPOUND OF NANOPARTICLES AND METHOD FOR PREPARING IT | 2014 |
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| VECTORIZED WATER-COMPATIBLE POLYMER MICELLAR PARTICLES FOR DELIVERY OF BIOLOGICALLY ACTIVE SUBSTANCES THROUGH BLOOD-BRAIN BARRIER | 2020 |
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| APTAMER PASSING THROUGH MOUSE BLOOD-BRAIN BARRIER OF MOUSE BRAIN | 2016 |
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| METHOD OF PRODUCING POLYMER NANOSPHERES FOR TARGETED DELIVERY TO TARGET TISSUE | 2019 |
|
RU2722822C1 |
| BLOOD BRAIN BARRIER SHUTTLE | 2013 |
|
RU2663120C2 |
| SHUTTLE FOR BLOOD-BRAIN BARRIER | 2013 |
|
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| BACTERIALLY DERIVED, INTACT MINICELLS FOR DELIVERY OF THERAPEUTIC AGENTS TO BRAIN TUMOURS | 2012 |
|
RU2664698C2 |
| POLYPEPTIDE CAPABLE OF OVERCOMING HEMATOENCEPHALIC BARRIER, AND CONJUGATE THEREOF | 2005 |
|
RU2408605C2 |
| APROTININ POLYPEPTIDES FOR TRANSPORT OF COMPOUND THROUGH BLOOD-BRAIN BARRIER | 2010 |
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RU2611193C2 |
