APROTININ POLYPEPTIDES FOR TRANSPORT OF COMPOUND THROUGH BLOOD-BRAIN BARRIER Russian patent published in 2017 - IPC C07K7/08 C07K19/00 A61K47/42 A61P35/00 

Abstract RU 2611193 C2

FIELD: biotechnology.

SUBSTANCE: present invention relates to biotechnology, namely to delivery of anti-cancer agents to mammal cells. Invention enables to obtain conjugate of Angiopep-2 polypeptide aprotinin with three taxol molecules, which can be used in therapy of patients suffering from cerebral cancer.

EFFECT: obtained conjugate can effectively overcome blood-brain barrier in mammal and deliver drug to brain cells.

3 cl, 9 dwg, 6 tbl, 3 ex

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RU 2 611 193 C2

Authors

Belivo Rishar

Demele Mishel

She Kristian

Redzhina Entoni

Dates

2017-02-21Published

2010-09-13Filed