METHOD OF ESTIMATING SENSITIVITY OF ENDOMETRIAL CANCER TO NEOADJUVANT APPLICATION OF AROMATASE INHIBITORS Russian patent published in 2009 - IPC A61B8/08 

Abstract RU 2373857 C1

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to oncoendocrinology and oncogynecology and is intended for estimation of endometrial cancer sensitivity to neoadjuvant therapy with aromatase inhibitors. Before and after the course of neoadjuvant therapy with aromatase inhibitors ultrasonic endometrium thickness by value of M-echo signal and marker Ki-67 expression; and laboratory indices - concentration of estradiole in blood and aromatase activity in tumor tissue are examined. Detected dynamic changes are given definite points. If sum of points is 4 and higher such patients and detected in them neoplasms are referred to group of sensitive to neoadjuvant therapy with aromatase inhibitors.

EFFECT: method allows to estimate potential efficiency of aromatase inhibitors in adjuvant regimen in endometrial cancer therapy.

2 ex, 2 tbl

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RU 2 373 857 C1

Authors

Bershtejn Lev Mikhajlovich

Danilova Marija Anatol'Evna

Kovalevskij Anatolij Jur'Evich

Turkevich Elena Aleksandrovna

Gershfel'D Ehduard Dmitrievich

Maksimov Sergej Janovich

Dates

2009-11-27Published

2008-04-17Filed