FIELD: medicine.
SUBSTANCE: invention relates to medicine, namely to oncoendocrinology and oncogynecology and is intended for estimation of endometrial cancer sensitivity to neoadjuvant therapy with aromatase inhibitors. Before and after the course of neoadjuvant therapy with aromatase inhibitors ultrasonic endometrium thickness by value of M-echo signal and marker Ki-67 expression; and laboratory indices - concentration of estradiole in blood and aromatase activity in tumor tissue are examined. Detected dynamic changes are given definite points. If sum of points is 4 and higher such patients and detected in them neoplasms are referred to group of sensitive to neoadjuvant therapy with aromatase inhibitors.
EFFECT: method allows to estimate potential efficiency of aromatase inhibitors in adjuvant regimen in endometrial cancer therapy.
2 ex, 2 tbl
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Authors
Dates
2009-11-27—Published
2008-04-17—Filed