FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to medicinal agents and combination for treatment of respiratory disease, such as asthma, acute or chronic bronchitis, emphysema, chronic obstructive pulmonary disease (COPD), bronchial hyperreactivity or rhinitis, containing efficient amount of (a) inhibitor PDE4 and efficient amount of (b) antagonist of muscarinic receptors M3, representing (3R)-1-phenethyl-3-(9H-xanthene-9-carbonyloxy)-1-azonibicyclo[2.2.2]octane, in the form of salt with anion X, representing pharmaceutically acceptable anion of mono- or polyvalent acid. Also application of (3R)-1-phenethyl-3-(9H-xanthene-9-carbonyloxy)-1-azonibicyclo[2.2.2]octane and inhibitor PDE4 is disclosed for production of medicinal agent for treatment of respiratory disease.
EFFECT: improved therapeutic effect in treatment of respiratory diseases.
19 cl, 7 ex
