2-PHENYLPROPIONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF Russian patent published in 2009 - IPC C07C309/73 C07C311/51 C07D207/16 C07D211/14 C07D277/46 A61K31/255 A61K31/40 A61K31/4453 A61K31/426 A61P9/10 A61P17/06 A61P19/02 

FIELD: medicine.

SUBSTANCE: there are described 2-(R)-phenylpropionic acid derivatives of formula (1) and their pharmaceutically acceptable salts where R' is chosen from H, OH and provided R' represents H, R is chosen from H, C₁-C₅-alkyl, C₃-C₆-cycloalkyl, C₁-C₃-alkoxy, thiazolyl, substituted CF₃, the remained formula -CH₂-CH₂-Z-(CH₂- CH₂O)nR', where n is equal to 2, and Z represents oxygen, the remained formula - (CH₂)n-NRaRb, the remained formula SO₂Rd, provided R' represents OH, R is chosen from C₁-C₅alkyl. The compounds are applied to inhibit chemotactic activation of neutrophils (PMN leukocytes) induced by interaction of interleukine-8 (IL-8) and membrane receptors CXCR1 and CXCR2. The compounds are applied to prevent and treat the pathologies generated by specified activation. There are also described application of the compounds for manufacturing of medicinal agents for treating psoriasis, nonspecific ulcerative colitis, melanoma, angiogenesis, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and to prevent and treat the damages caused by ischemia and reperfusion, the pharmaceutical composition and method for making the compounds of formula (1) where R' represents H and R - group SO₂Rd.

EFFECT: higher clinical effectiveness.

8 cl, 3 tbl, 11 ex