FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed invention relates to derivatives of (R)-2-arylpropionamides of general formula 
I, in which Ar is phenyl group, substituted in 3(meta) position by group R1, selected from: linear or branched C1-C8-alkanoyl, C3-C6- cycloalkanoyl, heteroarylcarbonyl, C1-C6-alkylaminocarbonyl, arylaminocarbonyl, C1-C6-alkylamino, C1-C6-acylamino, arylamino, benzoylamino, aryloxy, heteroaryl, C1-C6-alkoxycarbonyl, C6-aryloxycarbonyl, C1-C8-alkansulfonyl, arylsulfonyl, or 3,4-dihydro-1H-quinolyl-2-on; R is selected from: -H, OH; - heteroaryl group is selected from: pyridine, pyrimidine, pyrrole, thiophene, furan, indole, thiazole, oxazole; - α or β carboxyl residue can consist of straight or branched C1-C6-alkyl, C3-C6-cycloalkyl, optionally substituted with other carboxyl (COOH) group; - residue with formula SO2Rd, in which Rd is C1-C6-alkyl, C3-C6-cycloalkyl, C2-C6-alkenyl or pyridyl, on condition that compounds of formula I are not the following compounds: (R)-2-(3-phenoxyphenyl)-propanoyl-phenylglycine; (R)-2-( phenoxyphenyl)-propanoyl-glycine; (R)-2-[(3'-acetyl)phenyl]-R-4''-pyrimidyl)propionamide. Invention also relates to method of obtaining formulaI compound and application of formula I compound for preparation of medications for treatment of diseases including C5a induced hemotaxis of human PMNs.
EFFECT: obtained are novel derivatives of (R)-2-arylpropionamide, possessing useful biological properties.
9 cl, 3 dwg, 2 tbl, 34 ex
| Title | Year | Author | Number |
|---|---|---|---|
| (R)-ARYLALKYLAMINO DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | 2006 |
|
RU2458051C2 |
| (R)-2-ARYLPROPIONIC ACID OMEGA-AMINOALKYLAMIDE QUATERNARY AMMONIUM SALTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF | 2002 |
|
RU2291857C2 |
| (R)-4-(HETEROARYL)PHENYLEHTYL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | 2008 |
|
RU2475486C2 |
| 2-ARYLPROPIONIC ACIDS AND DERIVATIVES, AND PHARMACEUTICAL COMPOSITIONS, CONTAINING THEREOF | 2009 |
|
RU2520212C2 |
| (R)-2-ARYLPROPIONIC ACID OMEGA-AMINOALKYLAMIDES AS INHIBITORS OF POLYMORPHONUCLEAR AND MONONUCLEAR CELL HEMOTAXIS, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 2002 |
|
RU2272024C2 |
| AMIDINES AND THEIR DERIVATIVE, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF | 2004 |
|
RU2375346C2 |
| PYRIDIN DERIVATIVES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS | 2004 |
|
RU2353617C2 |
| (2R)-2-[(4-SULPHONYL)AMINOPHENYL]PROPANAMIDE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | 2007 |
|
RU2457201C2 |
| SULFONIC ACIDS, DERIVATIVES OF SAID ACIDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | 2004 |
|
RU2345063C2 |
| PIPERAZINE COMPOUND INHIBITING PROSTAGLANDIN-D-SYNTHASE | 2010 |
|
RU2496778C2 |
