(R)-4-(HETEROARYL)PHENYLEHTYL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Russian patent published in 2013 - IPC C07D413/12 C07D417/12 A61K31/427 A61K31/422 A61P37/00

Abstract RU 2475486 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to (R)-4-(heteroaryl)phenyl compounds of formula ,

where X represents heteroatom, selected from -S or O, Y represents H or residue, selected from group, consisting of - linear or branched C₁-C₄-alkyl, halogen-C₁-C₃-alkyl; Z represents heteroaryl ring, selected from group, consisting of unsubstituted tetrazole and triazole, pyrazole, thiazole, isoxazole, isothiazole, thiadiazole and oxadiazole, substituted with one hydroxyl group and optionally additionally substituted with linear C₁-C₄-alkyl. (R)-4-(heteroaryl)phenylethyl derivatives of formula (I), which can be used for application in treatment of diseases, into which C5a-induced human PMN-chemotaxis is involved. Formula (I) compounds, where Z represents tertazole, is obtained by interaction of formula

compound with trimethylsililazide.

EFFECT: obtaining (R)-4-(heteroaryl)phenylethyl derivatives, possessing high selectivity and activity in inhibition of C5a-induced chemotaxis of neutrophils.

7 cl, 1 tbl, 3 ex

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RU 2 475 486 C2

Authors

Morikoni Alessio

Aramini Andrea

Dates

2013-02-20—Published

2008-10-17—Filed