SUBSTITUTED PYRAZOLOPYRIDINES, CONTAINING COMPOSITIONS, METHOD FOR MAKING AND APPLICATION Russian patent published in 2009 - IPC C07D471/04 A61K31/437 A61P35/00 C07D213/84 C07D213/85 

FIELD: medicine.

SUBSTANCE: invention refers to substituted pyrazolopyridines representing compound of formula (I) , where: 1) Ar-L-A represents: where X2 is chosen from N and CH; 2) A represents phenyl optionally substituted with substitutes in number 1 to 3 chosen from (C1-C6)alkyl, halogenated (C1-C6)alkyl, halogen, OH, O-(C1-C6)alkyl, halogenated O-(C1-C6)alkyl, S-(C1-C6)alkyl, halogenated 8-(C1-C6)alkyl, COOH, N(R8)CO(R9) where R8 represents H or (C1-C6)alkyl, and R9 represents (C1-C6)alkyl; herewith if A is disubsituted, two substitutes A together with benzene ring form benzodioxol fragment; 3) L is chosen from the group composed of: NH-CO-NH, NH-SO₂; 4) one of radicals X, Y and Z is chosen from N, and other two radicals Z, Y and X represent CH; or to their pharmaceutically acceptable salts. The offered compounds inhibit reactions catalysed by kinase chosen from FAK, KDR and Tie2. Besides the inventive subject matters are a medicinal agent and a pharmaceutical composition applied for inhibition of specified kinases, particularly application of offered compounds for making the medicinal agent intended for therapy of cancer. There are also offered intermediate compounds for making the compound of formula I.

EFFECT: higher efficiency of new agents.

17 cl, 1 tbl, 41 ex