PYRAZOLQUINOLINES WITH IMMUNOMODULATING ACTIVITY Russian patent published in 2008 - IPC C07D471/04 C07D495/04 A61K31/382 A61K31/4162 A61P37/02 

FIELD: chemistry.

SUBSTANCE: invention relates to the novel compounds with the formula (I) or their pharmaceutically or veterinary-acceptable salts: where: R₁ and R₃ independently represent H; F; Cl; Br; C₁-C₆alkyl; R₂ represents H or C₃-C₇cycloalkyl; Y represents -S- or -N(R₅)-, where R₅ represents H; X represents the bind; R₄ represents -C(=O)NR₆R₇, where R₆ represents H or radical of formula -(Alk)_b-Q, where b is equal to 0 or 1, and Alk is not necessarily substituted with C₁-C₆alkyl, C₁-C₆alkoxi, F, Cl, Br, oxo, COOH, bivalent C₁-C₁₂alkylen, C₂-C₁₂alkenylen with direct or ramified chain, which can be disconnected with one ore several non-adjacent -O-, -S- or -N(R₈)-, where R₈ represents H or C₁-C₄alkyl, C₃-C₄alkenyl or C₃-C₆cycloalkyl, and Q represents H; -SH; -NR₈R₈, where each R₈ can be similar or different; the complex ether group; or not necessarily substituted with C₁-C₆alkyl, C₁-C₆alkoxi, phenyl, benzyl, phenoxy, C₃-C₈cycloalkyl, amino, fluor, bromine, oxo, -COOH, -COR^A, -COOR^A, NHR^A, -NR^AR^B, where R^A and R^B are independent (C₁-C₆)alkyl group, phenyl, C₃-C₇cycloalkyl, C₅-C₇cycloalkenyl or heterocyclilc ring containing 5 to 8 ring atoms; and R₇ represents H or C₁-C₆alkyl; or, taken together with atom or atoms, they are bound with, R₆ and R₇ form not necessarily substituted with (C₁-C₆)alkyl, COOR^A, where R^A is the (C₁-C₆)alkyl group, phenyl, not necessarily substituted with F, Cl, Br, heterocyclilc ring containing 5 to 8 ring atoms. The invention also relates to N-(3-dimethylaminopropyl)-4-(4-cyclopropyl-3-oxo-3,5-dihydropirazol[4,3-c]quinoline-2-il]benzamide; to application of the compounds; to the immunomodulation method and to the pharmaceutical and veterinary composition.

EFFECT: production of novel immunobiologic compounds.

14 cl, 173 ex, 1 tbl