FIELD: medicine.
SUBSTANCE: there are described new isoindole derivatives of general formula (1), 
wherein A1, A2 and A4 stands for CH, and A3 means N or C-OH; n is equal to 2; R1 represents O; R2-stands for H; and a pharmaceutical composition containing thereof.
EFFECT: new compounds are inhibitors of chaperone protein Hsp90 activity and can be used in chemotherapy of cancerous diseases.
6 cl, 3 ex
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|
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