METHOD FOR PRODUCTION OF COMBINED LIPOSOME ANTIBACTERIAL PREPARATION Russian patent published in 2009 - IPC A61K9/127 A61K31/7036 C07H15/236 A61K31/496 

FIELD: medicine.

SUBSTANCE: invention is related to medicine, namely to method for production of liposome forms of antimicrobial preparations for treatment and prophylaxis of special danger infectious diseases. Method includes the following: solution of lipid and rifampicin shots in chloroform, preparation of gentamicin sulfate solution, creation of emulsion from chloroform solution of lipids with rifampicin, production of liposomes by evaporation with reversion of phases, removal of rifampicin that is non-included into membrane as well as gentamicin sulfate that is non-included inside vesicle by means of centrifugation, differing by the fact that in process of liposomes preparation by addition to chloroform mixture of rifampicin lipids in organic phase and increase of lipid load, high stability of emulsion and gel of "water in oil" type is achieved, which made it possible to build-in antibiotic into membrane. Universality of carrier is provided by neutral charge of liposome membrane. Used method makes it possible to apply one organic dissolvent with a certain temperature of boiling.

EFFECT: production of emulsion on rotor mixer eliminates toxic effect of titanium ions (titanium probe of ultrasonic disintegrator) onto membrane of liposomes and antibacterial preparations, reduces treatment time.

2 ex, 1 dwg