METHOD OF PRODUCING NIOSOMAL FORM OF OFLOXACIN Russian patent published in 2016 - IPC A61K31/538 A61K47/34 B82B3/00 

FIELD: medicine; biotechnologies.

SUBSTANCE: invention can be used for microencapsulation of antibacterial preparations into niosomes. Method of producing niosomal form of ofloxacin by reverse-phase distillation is carried out as follows. Chloroform solution containing sorbitan monostearate Span 60, cholesterol, polyethylene glycol PEG-4000 and dicetylphosphate in molar ratio of 35:27:1:5 respectively, is mixed with aqueous phase containing ofloxacin, at ratio of 5:1 by volume and emulsified with help of ultrasonic disintegrator for 5 minutes (amplitude of 7.5 mcm, 20 kHz). Then chloroform is removed by distillation at low pressure using rotary evaporator. To obtained surfactant lipid gel added 20 % of initial volume of aqueous phase and hydration of gel for 1 hour at (50±1) °C is carried out, then niosomes dispersion is maintained at temperature of (22±2) °C for 12 hours.

EFFECT: method enables obtaining PEG-containing niosomal forms of ofloxacin with high efficiency of activation of active substance (up to 76 %).

1 cl, 2 ex