FIELD: medicine.
SUBSTANCE: invention is related to crystalline polymorphous modification of hydrochloride [6,7-bis(2-methoxyethoxy)chinazoline-4-yl]-(3-ethynyl phenyl)amine. Crystalline polymorphous modification has powdery X-ray diffraction pattern, in which there are characteristic maxima, expressed in degrees of angle 2-theta ± 0.2 degrees: 5.7; 9.7; 10.1; 11.3; 17.0; 17.4; 18.9; 19.6; 21.3; 22.8; 23.6; 24.2; 24.7; 25.4; 26.2; 26.7; 29.3. Invention is also related to method for production of crystalline polymorphous modification, to pharmaceutical composition, having inhibiting action in respect to tyrosine kinase ferments, including crystalline polymorphous modification, to use of crystalline polymorphous modification for preparation of medicinal agents.
EFFECT: improved efficiency of compound use.
12 cl, 6 dwg, 9 ex
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