PYRROLE COMPOUNDS AS INHIBITORS OF ERK PROTEIN KINASES, THEIR SYNTHESIS AND INTERMEDIATE COMPOUNDS Russian patent published in 2009 - IPC C07D401/04 A61K31/4439 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention is related to compounds of formula I , or its pharmaceutically acceptable salt of this, in which: R¹ means C_1-6-aliphatic group, besides, R¹ may be substituted with substituents in number of up to 2 groups, independently selected from -OR or -C_1-3 halogenalkyl; each R independently means hydrogen or C_1-4-aliphatic group; R² means R, fluorine or chlorine; m means 0, 1 or 2; and R³ means hydrogen, C_1-3-aliphatic group, fluorine or chlorine, to composition for inhibition of activity of protein kinase ERK1 or ERK2, on the basis of these compounds, to method for inhibition of activity of protein kinase ERK1 or ERK2, and also to use of compounds of formula I or composition on their basis, for treatment or reduction of disease severity.

EFFECT: new compounds are produced and described, which may be used as inhibitors of protein kinases.

11 cl, 7 ex, 3 tbl