SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES Russian patent published in 2014 - IPC C07D209/04 C07C211/40 C07D333/10 A61K31/135 A61K31/132 A61K31/381 A61K31/404 A61P25/00 A61P1/00 A61P9/00 

FIELD: chemistry.

SUBSTANCE: invention relates to novel 4-aminocyclohexane derivatives, having affinity for the µ- opioid receptor and ORL1 receptor. In formula

Y₁, Y₁', Y₂, Y₂', Y₃, Y₃', Y₄ and Y₄' denote -H; Q denotes -R₀, -C(O)-R₀ or -C(=NH)-R₀; R₀ and R₃ in each case independently denote -C_1-8-aliphatic, -aryl, -heteroaryl, -C_1-8-aliphatic-C₅-cycloaliphatic, -C_1-8-aliphatic-aryl; R₁ and R₂ independently denote unsubstituted -C_1-8-aliphatic; -C_1-8-aliphatic-C₅-cycloaliphatic, -C_1-8-aliphatic-aryl; n denotes 0; X denotes -NR_a-; R_a denotes unsubstituted -C_1-8-aliphatic; R_b denotes unsubstituted -C_1-8-aliphatic; "aliphatic" represents a straight saturated hydrocarbon residue which is unsubstituted or mono- or multi-substituted with F atoms; "cycloaliphatic" represents a saturated, unsubstituted monocyclic hydrocarbon residue with 5 carbon atoms in the ring; "aryl" represents phenyl, which can be substituted with -F, -R₀ and -OR₀; "heteroaryl" represents a 5-member cyclic aromatic moiety containing 1 heteroatom. The heteroatom is N or S, and the heterocyclic ring can be substituted with -F, -R₀ and -OR₀; the heterocyclic ring can be part of a bicyclic system including phenyl.

EFFECT: invention also relates to a drug containing said compounds and use of the compounds to produce a drug for treating pain, stress, epilepsy, learning and memory disorders, drug dependence, cardiovascular diseases, eating disorders and locomotory impairments.

9 cl, 10 tbl, 164 ex