FIELD: medicine.
SUBSTANCE: protein is constructed, which includes DNA-binding domain SSBTne from thermophile microorganism Termatoga neapolitana, connected to C-end of domain VirD2 from Agrobacterium tumefaciens, which is a signal of nuclear localisation.
EFFECT: efficient transport of transgene into cell nucleus.
6 dwg, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| COMPOSITIONS AND METHODS FOR MODIFICATION OF SPECIFIED TARGET NUCLEIC ACID SEQUENCE | 2012 |
|
RU2663354C2 |
| METHOD OF PRODUCING PLASMID DNA IN POLYMER NANOSPHERES FOR DELIVERY | 2022 |
|
RU2817116C1 |
| RECOMBINANT PROTEIN CONSTRUCT DSD-sp-β-GAL EXHIBITING ENZYMATIC ACTIVITY OF THERMOSTABLE β-GALACTOSIDASE (LACTASE) AND AFFINE CONNECTABLE WITH DEXTRANE, PLASMID DNA pGD-10 DETERMINING DSD-sp-β-GAL BIOSYNTHESIS, AND Escherichia coli DH5α/PGD-10 PRODUCER STRAIN | 2009 |
|
RU2428477C2 |
| PCDEXO-GS-SSB GENETIC CONSTRUCTS CONTAINING SEQUENCES ENCODING CHIMERIC SSB PROTEINS AND EXONUCLEASES OF THE BACTERIOPHAGE HOMOLOGOUS RECOMBINATION APPARATUS, COMBINED VIA A GLYCINE-SERINE POLYLINKER | 2020 |
|
RU2763747C1 |
| HISTONES AND BIODEGRADABLE LIPIDES AS MEANS FOR NUCLEIC ACIDS DELIVERY TO EUKARYOTIC CELLS | 2015 |
|
RU2637371C2 |
| METHODS AND COMPOSITIONS FOR TREATING HEMOPHILIA B | 2011 |
|
RU2608643C2 |
| PaCas9 NUCLEASE | 2018 |
|
RU2706298C1 |
| METHOD OF OBTAINING SYSTEM OF DIRECTED DELIVERY OF PROTEIN MOLECULES (ONCOLYTIC PROTEINS) INTO TUMOUR CELLS BASED ON ACTIVATED LYMPHOCYTES | 2013 |
|
RU2552609C1 |
| METHOD FOR Trib-2mut RECOMBINANT ELASTROMERIAL DOMAIN, PRODUCTION, GENE-ENGINEERING pGDTrib2mut CONSTRUCTION, DETERMINING Trib-2mut BIOSYNTHESIS IN E.coli CELLS, E.coli M15/pGDTrib2mut PRODUCING STRAIN AND METHOD FOR POLYMER MATERIAL OBTAINING BASED ON THIS PROTEIN | 2015 |
|
RU2631004C2 |
| MOLECULAR CONJUGATES WITH POLYCATIONIC SECTION AND LIGAND FOR DELIVERY OF DNA AND RNA INTO CELL AND CELL NUCLEUS | 2009 |
|
RU2537262C2 |
