COMPOUNDS (R)-5-CARBAMOYL-8-FLUORO-3,N,N-DISUBSTITUTED AMINO-3,4-DIHYDRO-2H-1-BENZOPYRANES, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT OF PATIENTS AND METHODS OF SYNTHESIS OF COMPOUNDS Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes new compounds of the general formula (I) where R₁ is n-propyl or cyclobutyl; R₂ is isopropyl, tertiary butyl, cyclobutyl, cyclopentyl or cyclohexyl; R₃ is hydrogen atom; R₄ is hydrogen atom or methyl as (R)-enantiomer in the form of free base or its pharmaceutically acceptable salt showing selective affinity to 5ГT_IA-receptors of the mammalian central nervous system and these compounds show an antagonistic activity simultaneously. Invention describes also methods of synthesis of the above indicated compounds of the formula (I). EFFECT: improved method of synthesis, valuable pharmacological properties. 25 cl, 3 tbl, 9 ex