METHOD FOR STEREOSELECTIVE SYNTHESIS OF 2,4-CIS-8-ANTI-TRIALKYL-3-THIA-1,5-DIAZABICYCLO[3,2,1]OCTANES Russian patent published in 2010 - IPC C07D471/08 

Abstract RU 2378276 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a method for synthesis of 2,4-cis-8-anti-trialkyl-3-thia-1,5-diazabicyclo[3.2.1]octanes with general formula: The method involves reacting aliphatic aldehyde (acetic, propionic, butyric, valerianic, caproic) saturated with hydrogen sulphide with 1,2-diaminoethane in molar ratio diamine:aldehyde:hydrogen sulphide equal to 1:3:2, at 0°C for 3 hours. 2,4-cis-8-anti-trialkyl-3-thia-1,5-diazabicyclo[3.2.1]octanes can be used as selective sorbents and extraction agents of precious metals, as antibacterial, antiviral, fungicidal and acaricidal agents.

EFFECT: stereoselective synthesis of one conformationally pure 2,4-cis-8-anti-trialkyl-3-thia-1,5-diazabicyclo[3,2,1]octane isomer; the method is also distinguished by simplicity of carrying experiments and availability of initial reagents.

1 cl, 1 ex, 1 tbl

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RU 2 378 276 C1

Authors

Akhmetova Vnira Rakhimovna

Vagapov Ruslan Adgamovich

Nadyrgulova Guzel' Razhapovna

Rakhimova Elena Borisovna

Tjumkina Tat'Jana Viktorovna

Kunakova Rajkhana Valiullovna

Dzhemilev Usein Memetovich

Dates

2010-01-10Published

2008-06-23Filed