NOVEL HEXAFLUOROISOPROPANOL DERIVATIVES Russian patent published in 2010 - IPC C07C215/68 C07D277/28 C07D213/38 C07D233/58 C07D263/32 A61K31/135 A61K31/426 A61K31/44 A61K31/381 A61K31/421 A61P3/06 

FIELD: chemistry.

SUBSTANCE: present invention relates to compounds of formula (I) and their pharmaceutically acceptable salts and esters. The disclosed compounds have LXR-alpha and/or LXR-beta agonist properties. In formula (I) R¹ is hydrogen, halogen; R² is lower alkyl, flouro-lower alkyl; R³ is hydrogen, phenyl; R⁴ is hydrogen, hydroxy; R⁵ is hydrogen; phenyl; R⁶ is phenyl, a 5-6-member heteroaryl with one or two heteroatoms selected from nitrogen and sulphur, a 9-member bicyclic heteroaryl with a sulphur atom as a heteroatom, which can be optionally substituted with a halogen, or R⁶ is , R⁷ is a lower alkyl; R⁸ is phenyl which is optionally substituted with one substitute selected from a group consisting of halogen, fluoro-lower alkyl, R⁹-O-C(O)-, R¹⁰R¹¹NC(O)-, phenyl-lower alkoxy; R⁹, R¹⁰, R¹¹ independently represent hydrogen or lower alkyl; L is a single bond, lower alkylene or lower alkenylene; m assumes values from 0 to 3; n is equal to 0 or 1.

EFFECT: obtaining a new compound and a pharmaceutical composition which contains the disclosed compound as an active ingredient for therapeutic and/or preventive treatment of diseases.

23 cl, 47 ex