SUBSTITUTED QUINOXALINE-TYPE BRIDGE PIPERIDINE COMPOUNDS AND USE THEREOF Russian patent published in 2013 - IPC C07D403/04 A61K31/498 A61K31/46 A61P25/04 

FIELD: chemistry.

SUBSTANCE: invention relates to substituted quinoxaline-type bridge piperidine compounds of formula

,

or pharmaceutically acceptable derivatives thereof, where: a equals 0; b is an integer selected from 0 or 1; each R₅ is independently selected from -H; R¹ is -(C₉-C₁₄)bicycloalkyl, each substituted with 1 or 2 independently selected R₃ groups; each R₃ independently selected from -(C₁-C₄)alkyl. The invention also relates to a pharmaceutical composition, capable of modulating ORL-1 receptor function, based on said compound.

EFFECT: obtaining novel compounds which can be used in medicine to treat pain, memory disorder, obesity, constipation, depression, dementia, Parkinsonism, anxiety, cough, diarrhoea, high blood pressure, epilepsy, anorexia, urinary incontinence or drug dependence.

27 cl, 2 tbl, 19 ex