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(19)

(11)

2 384 585

(13)

(51)

IPC

C07K5/65(2006-01-01)

C07K5/83(2006-01-01)

C07K5/107(2006-01-01)

A61K38/05(2006-01-01)

A61K38/06(2006-01-01)

A61K38/07(2006-01-01)

A61P25/00(2006-01-01)

(21) (22)

Application

2006143664/04, 2005-05-09

(24)

Start date

2005-05-09

(22)

Actual filing date

2005-05-09

(45)

Published

2010-03-20

(72)

Inventor

Smit Mark S.Lehjdig Gaj Dzh.Borchardt Ronal'D T.B'Junin Barri A.Kruz Krejg M.Masser Dzhon Kh.Shenk Kevin D.Rehjdel Peggi A.

(73)

Holder

Proteoliks, Ink.

ENZYME INHIBITING COMPOUNDS Russian patent published in 2010 - IPC C07K5/65 C07K5/83 C07K5/107 A61K38/05 A61K38/06 A61K38/07 A61P25/00

Abstract RU 2384585 C2

FIELD: chemistry.

SUBSTANCE: invention relates to α',β'-epoxides of peptides of formulae (III) and (IV) which inhibit chymotrypsin-like activity of 20S proteasome.

EFFECT: increased effectiveness of the compounds.

19 cl, 29 ex

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RU 2 384 585 C2

Authors

Smit Mark S.

Lehjdig Gaj Dzh.

Borchardt Ronal'D T.

B'Junin Barri A.

Kruz Krejg M.

Masser Dzhon Kh.

Shenk Kevin D.

Rehjdel Peggi A.

Dates

2010-03-20—Published

2005-05-09—Filed