ANTIVIRAL COMPOUNDS Russian patent published in 2014 - IPC C07D471/04 A61K31/519 A61K31/4375 A61P31/14 

FIELD: chemistry.

SUBSTANCE: in formula III:

,

each of X₁ and X₂ is independently selected from a bond, -CH₂-, -O- or -S- and at least one of X₁ and X₂ is selected from -CH₂-, -O- or -S-; each of R₇ and R₈ is independently selected from hydrogen or C₆aryl, optionally substituted with one or more R_a and at least one of R₇ and R₈ is selected from C₆aryl, optionally substituted with one or more R_a; each of Z₁ and Z₂ is selected from -N(R_B)-, each of W₁, W₂, W₃, W₄, W₅, W₆, W₇ and W₈ is independently selected from N or C(R_d), where R_d in each case is selected from hydrogen; each of R₁, R₂, R₉, R₁₁, R₁₂, R₁₄, R₁₅ and R₁₆ in each case is independently selected from hydrogen or R_a; each of m and n is 0; R_a in each case is independently selected from halogen, hydroxy group, amino group, -L_A and -L_s-R_e; L_a in each case is selected from C₁-C₆-alkyl; values of radicals T, R_b, R_b', R_e are given in the claim. The invention also relates to a pharmaceutical composition containing said compounds, a method of inhibiting HCV replication, a method of treating HCV infection and a method of producing said compounds.

EFFECT: high efficiency of using compounds.

7 cl, 6 tbl, 28 ex