FIELD: chemistry.
SUBSTANCE: present invention provides novel methods for synthesis of (S)-6-chloro-4-cyclopropylethinyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one of formula 
, which is useful as an inhibitor of reverse transcriptase of the human immunodeficiency virus (HIV).
EFFECT: method avoids use toxic ingredients, as well as release of an intermediate compound at the cyclisation stage.
2 cl
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