FIELD: chemical industry. SUBSTANCE: method comprises reacting 3-(2- aminoethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-one (II) with isoxazole derivative of formula III 
wherein Y and Z are removable groups such as halogen or alkyl-or arylsulfonyloxy group in the presence of suitable solvent and base. The method makes it possible to simplify process for preparation of compound (I) due to using more readily available reagents. The present invention also describes compounds II and III. EFFECT: more efficient preparation method. 8 cl, 8 ex
| Title |
Year |
Author |
Number |
| 3-{2-[4-(6-FLUOROBENZO[D]ISOXAZOLE-3-YL)-3,6-DIHYDRO-2H- -PYRIDINE-1-YL]-ETHYL}-2-METHYL-6,7,8,9-TETRAHYDROPYRIDO- -[1,2-A]-PYRIMIDINE-4-ONE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF ITS SYNTHESIS, METHOD OF PRODUCING SALT OF 1-[2-(2-METHYL-4-OXO-6,7,8,9-TETRAHYDRO-4H-PYRIDO-[1,2-A]- -PYRIMIDINE-3-YL)ETHYL]-4-(6-FLUOROBENZO[D]ISOXAZOLE-3-YL)- -PYRIDINIUM, PHARMACEUTICAL COMPOSITION |
1995 |
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- Fransisko Markil'Jas Olondris
- Pere Dalmases Barkhoan
- Anna Bosh Rovira
- Khoan Roka Asin
- Khuan Karlos Del' Kastil'O N'Eto
|
RU2126005C1 |
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2003 |
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|
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1993 |
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|
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|
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1993 |
- Pere Dal'Mases Barkhoan[Es]
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|
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|
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2004 |
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