1H-INDAZOLES, BENZOTHIAZOLES, 1,2-BENZOISOXAZOLES, 1,2-BENZOISOTHIAZOLES AND CHROMONES AND SYNTHESIS AND USE THEREOF Russian patent published in 2010 - IPC C07D471/08 C07D487/08 A61K31/551 

FIELD: chemistry.

SUBSTANCE: described is a compound selected from formulae , , , , and , where X¹ denotes CH; X²-X⁵ each independently denotes CH or C-, where -C represents the point where group B is bonded and where one of X²-X⁵ denotes -C; X⁷-X¹⁰ each independently denotes CH or CR²; X¹⁸-X²¹ each independently denotes CH or CR⁵; X²² and X²³ each independently denotes CH or CR¹², where at least one of X²² and X²³ denotes CR¹²; X²⁴ denotes CH; B denotes CH₂ or C=O; B¹ denotes CH; Y denotes oxygen or sulphur; Z denotes O; m equals 2; R denotes hydrogen or R denotes each indendently (C₁-C₆)alkyl, (C₃-C₈)cycloalkyl, halogen, imidazolyl substituted with (C₁-C₆)alkyl and/or an oxo group or OR⁹; R⁹ denotes hydrogen, (C₁-C₆)alkyl which is unsubstituted or substituted with once or several times with fluorine, or (C₄-C₈)cycloalkylalkyl; R¹² denotes a (C₁-C₆)alkoxy group which is substituted once or several times with fluorine, unsubstituted thiazolyl, thiazolyl which is substituted with (C₁-C₆)alkyl, unsubstituted oxazolyl, dihydropyranyl, tetrahydropyranyl or tetrahydropyranyloxy, and pharmaceutically acceptable salts of the said compounds. Described also are pharmaceutical compositions containing the said compounds.

EFFECT: invention relates to ligands of nicotinic acetylcholine receptors (nAChR), activation of nAChRs and treatment of diseases associated with defective or with functional disorders of nicotinic acetylcholine receptors, especially in the brain.

69 cl, 55 ex