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2 387 456

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(51)

IPC

A61K48/00(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2008134783/14, 2008-08-28

(24)

Start date

2008-08-28

(22)

Actual filing date

2008-08-28

(45)

Published

2010-04-27

(72)

Inventor

Shurdov Mikhail Arkad'EvichBogachev Sergej StanislavovichRogachev Vladimir AlekseevichNikolin Valerij PetrovichPopova Nelli AleksandrovnaLikhacheva Anastasija SergeevnaSebeleva Tamara EgorovnaStrunkin Dmitrij NikolaevichShilov Aleksandr Gennad'EvichChernykh Elena RehmovnaGel'Fgat Evgenij L'VovichAljamkina Ekaterina Anatol'EvnaDolgova Evgenija Vladimirovna

(73)

Holder

Shurdov Mikhail Arkad'EvichBogachev Sergej Stanislavovich

ONCOTHERAPY Russian patent published in 2010 - IPC A61K48/00 A61P35/00

Abstract RU 2387456 C1

FIELD: medicine.

SUBSTANCE: therapy involves introduction of sonicated human DNA combined with nonhistone protein to the patient with the length of human DNA fragments making 200-6000 pairs of bases, and the ratio of sonicated human DNA/nonhistone protein being 1/0.8. The complex is administered in a dose to ensure the blood concentration of sonicated human DNA 25 ng/ml - 1000 ng/ml.

EFFECT: application of the invention implies oncotherapy ensured by substitution of replacement oncolocus by a DNA fragment with nonmutant allele to form a nucleotide stable complex.

2 cl, 4 tbl, 11 dwg

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RU 2 387 456 C1

Authors

Shurdov Mikhail Arkad'Evich

Bogachev Sergej Stanislavovich

Rogachev Vladimir Alekseevich

Nikolin Valerij Petrovich

Popova Nelli Aleksandrovna

Likhacheva Anastasija Sergeevna

Sebeleva Tamara Egorovna

Strunkin Dmitrij Nikolaevich

Shilov Aleksandr Gennad'Evich

Chernykh Elena Rehmovna

Gel'Fgat Evgenij L'Vovich

Aljamkina Ekaterina Anatol'Evna

Dolgova Evgenija Vladimirovna

Dates

2010-04-27—Published

2008-08-28—Filed