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IPC

A61K31/675(2006-01-01)

A61K31/711(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2013143563/15, 2013-09-27

(24)

Start date

2013-09-27

(22)

Actual filing date

2013-09-27

(45)

Published

2015-02-20

(72)

Inventor

Shurdov Mikhail Arkad'EvichBogachev Sergej StanislavovichAndrushkevich Mikhail MikhajlovichAljamkina Ekaterina Anatol'EvnaDolgova Evgenija VladimirovnaRogachev Vladimir AlekseevichNikolin Valerij PetrovichPopova Nelli AleksandrovnaChernykh Elena RehmovnaTaranov Oleg SvjatoslavovichProskurina Anastasija SergeevnaMinkevich Aleksandra MikhajlovnaSidorov Sergej Vasil'EvichOstanin Aleksandr Anatol'EvichBajborodin Sergej IvanovichEfremov Jaroslav Rejngol'DovichAndrushkevich Oleg MikhajlovichOmigov Vladimir Vilor'EvichKozel Artem Viktorovich

(73)

Holder

Shurdov Mikhail Arkad'EvichBogachev Sergej StanislavovichAndrushkevich Mikhail Mikhajlovich

METHOD FOR ERADICATION OF INITIATING CANCER STEM CELLS Russian patent published in 2015 - IPC A61K31/675 A61K31/711 A61P35/00

Abstract RU 2542410 C1

FIELD: medicine.

SUBSTANCE: cyclophosphane 200 mg/kg is injected into experimental animals carrying developed ascytis. Then, a DNA preparation is administered intraperitoneally every hour after administering cyclophosphane for 12 hours. The DNA preparation consists of a mixture of preparations of fragmented human DNA and cross-linked human DNA processed in nitrogen mustard.

EFFECT: method provides the effective eradication of cancer stem cells by the synergism of the cytostatic and DNA preparation.

3 cl, 5 dwg

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RU 2 542 410 C1

Authors

Shurdov Mikhail Arkad'Evich

Bogachev Sergej Stanislavovich

Andrushkevich Mikhail Mikhajlovich

Aljamkina Ekaterina Anatol'Evna

Dolgova Evgenija Vladimirovna

Rogachev Vladimir Alekseevich

Nikolin Valerij Petrovich

Popova Nelli Aleksandrovna

Chernykh Elena Rehmovna

Taranov Oleg Svjatoslavovich

Proskurina Anastasija Sergeevna

Minkevich Aleksandra Mikhajlovna

Sidorov Sergej Vasil'Evich

Ostanin Aleksandr Anatol'Evich

Bajborodin Sergej Ivanovich

Efremov Jaroslav Rejngol'Dovich

Andrushkevich Oleg Mikhajlovich

Omigov Vladimir Vilor'Evich

Kozel Artem Viktorovich

Dates

2015-02-20—Published

2013-09-27—Filed