METHOD OF OBTAINING STIMULATED DENDRITE CELLS FOR INDUCTION OF IMMUNE RESPONSE AGAINST HUMAN TUBERCULOSIS Russian patent published in 2010 - IPC A61K39/00 C12N5/784 A61P31/06 

Abstract RU 2401664 C1

FIELD: medicine.

SUBSTANCE: invention relates to biotechnology and can be used in treatment of diseases, namely oncologic ones. Method is based on sampling from patient immature dendrite cells, their cultivation ex vivo for maturing and formation of allostimulating activity. Cells are additionally collected with antigen and are introduced to the same patient for formation of adaptive immunity. During cultivation ex vivo of immature dendrite cells fragmented allogenic double-stranded genomic DNA with fragments with size 200-6000 bp is introduced into culture medium in amount 5 mcg/ml of medium.

EFFECT: invention allows to extend field of obtained product application with increase of general immune state of patients.

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Authors

Aljamkina Ekaterina Anatol'Evna

Dolgova Evgenija Vladimirovna

Likhacheva Anastasija Sergeevna

Rogachev Vladimir Alekseevich

Sebeleva Tamara Egorovna

Nikolin Valerij Petrovich

Popova Nelli Aleksandrovna

Sakhno Ljudmila Vasil'Evna

Gel'Fgat Evgenij L'Vovich

Ostanin Aleksandr Anatol'Evich

Chernykh Elena Rehmovna

Zagrebel'Nyj Stanislav Nikolaevich

Bogachev Sergej Stanislavovich

Shurdov Mikhail Arkad'Evich

Dates

2010-10-20Published

2009-08-03Filed