PHENYL DERIVATIVES CONTAINING ACETYLENE GROUP Russian patent published in 2010 - IPC C07C59/68 C07C59/70 C07D213/30 C07D239/26 C07C323/20 C07C69/736 A61P3/10 A61K31/192 C07C235/34 

FIELD: chemistry.

SUBSTANCE: in formula (I) X¹ is O; R¹ is hydrogen; R² is hydrogen or C_1-7-alkyl, R³ is hydrogen or C_1-7-alkyl; R⁴ and R⁸ are independently selected from a group consisting of hydrogen, C_1-7-alkyl and halogen; R⁵, R⁶ and R⁷ are independently selected from a group consisting of hydrogen and halogen; and one of R⁵, R⁶ and R⁷ is a group, where X² is selected from a group consisting of S, O, NR⁹ and (CH₂)_pNR⁹CO; R⁹ is selected from a group consisting of hydrogen and C_1-7-alkyl; R¹⁰ is C_1-7-alkyl; R¹¹ is selected from a group consisting of hydrogen and C_1-7-alkyl; or R¹⁰ and R¹¹ together with the carbon atom with which they are bonded form a C_3-6-cycloalkyl ring; o equals 0, 1 or 2; n equals 0, 1, 2 or 3; p equals 0 or 1; and the sum of m, n and o assumes values from 1 to 5; R¹² is phenyl optionally substituted with fluoro-C_1-7-alkoxy, halogen, C_1-7-alkoxy, fluro-C_1-7-alkyl; or R¹² is pyridine or pyrimidine substituted with fluoro-C_1-7-alkyl; and their pharmaceutically acceptable salts and/or esters. Present invention also relates to pharmaceutical compositions which have agonistic effect on PPARδ and/or PPARα containing such compounds.

EFFECT: new compounds have useful biological properties.

20 cl, 36 ex